Protein Post-translational Modifications and Cell Signaling

Developing and applying chemical methods, such as protein semisynthesis and molecular probes, to investigate protein ubiquitination, phosphorylation, and other PTMs in key enzyme and cellular signaling pathways.

Diagram showing the relationship between genome, transcriptome, and proteome diversity, illustrating gene transcription, RNA splicing, RNA editing, post-translational modification, and increasing complexity in protein diversity.

Ubiquitination Mechanisms

Exploring the regulatory mechanisms of ubiquitin and ubiquitin-like modifications and their pathological roles in disease progression to identify novel therapeutic targets.

Diagram illustrating catalytic mechanism of E3 ligase, ubiquitination chain types, and substrate selectivity with various substrate molecules in different colors.

Chemical Biology Tool Development

Designing and optimizing chemical and synthetic biology tools for targeted ubiquitination to provide innovative methods for basic research and translational medicine.

Schematic illustration of a scientific process showing chemical structures on the left, a circular arrow indicating a cycle in the middle, and laboratory equipment with a mass spectrometry graph, a DNA structure, and a protein diagram on the right.